3D-QSAR studies of Dipeptidyl peptidase IV inhibitors using a docking based alignment

Abstract  Dipeptidyl peptidase IV (DPP-IV) deactivates the incretin hormones GLP-1 and GIP by cleaving the penultimate proline or alanine from the N-terminal (P1-position) of the peptide. Inhibition of this enzyme will prevent the degrad