12-Lipoxygenase Induces Apoptosis of Human Gastric Cancer AGS Cells via the ERK1/2 Signal Pathway

Abstract  12-Lipoxygenase (12-LOX) is over-expressed in a variety of human tumors, but its exact effect on the tumorogenesis of gastric cancer remains largely obscure. To investigate the effect of 12-LOX and its inhibitor baicalein on pr