Sunday, August 24, 2008
An update on the biology and physiology of resistin
Abstract. Resistin is a newly discovered adipocyte hormone. It is related to resistin-like molecules , and in structure and function. Resistin is produced by white and brown adipose tissues but has also has been identified in several other ti
An update on autonomic neuropathy affecting the gastrointestinal tract
Abstract Gastrointestinal symptoms and disordered gut motility occur frequently in the diabetic population and are generally regarded as manifestations of gastrointestinal "autonomic dysfunction," although the relationships between both
An Odyssey of Islet Transplantation for Therapy of Type 1 Diabetes
Abstract Canadian surgical contributions to the field of islet transplantation have a rich heritage and a promising future. In this article, some seminal Canadian contributions to this field are reviewed, including contributions at the
An investigation of genome-wide associations of hypertension with microsatellite markers in the family blood pressure program (FBPP)
Abstract The Family Blood Pressure Program (FBPP) has data on 387 microsatellite markers in 13,524 subjects from four major ethnic groups. We investigated genetic association with hypertension of the linkage markers. Family-based method
Active integration: new strategies for transgenesis
Abstract This paper presents novel methods for producing transgenic animals, with a further emphasis on how these techniques may someday be applied in gene therapy. There are several passive methods for transgenesis, such as pronuclear
Active immunization against nicotine alters the distribution of nicotine but not the metabolism to cotinine in the rat
Abstract We have previously shown that active immunization with the nicotine immunoconjugate IP18-KLH attenuates the reinforcing effects of nicotine, i.e., suppresses the nicotine-induced brain dopamine release and prevents reinstatement of the
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