Activation of glycogen synthase kinase-3 induces Alzheimer-like tau hyperphosphorylation in rat hippocampus slices in culture

Summary.  Formation of neurofibrillary tangle from hyperphosphorylated tau is one of the hallmark lesions seen in Alzheimer’s disease (AD) brain, and neuronal deregulation of glycogen synthase kinase-3 (GSK-3) activity plays key ro