Activation of k1-opioid receptor as a method for prevention of ischemic and reperfusion arrhythmias: Role of protein kinase C and KATP channels

Abstract  Intravenous pretreatment with κ-opioid receptor antagonist (−)-U-50,488 (1 mg/kg) improved heart resistance to the arrhythmogenic effect of coronary occlusion and reperfusion. Selective κ1-opioid receptor antago